Endocrine Abstracts

Backgroud: Recent studies have shown an association between thyroid hormone levels and non-alcoholic fatty liver disease(NAFLD). However, there have been some inconsistencies between studies. Here, we evaluated the relationship between thyroid hormone levels and NAFLDin euthyroid subjects.Methods: A retrospective analysis of 27.719 euthyroid subjects who participated in comprehensive health examinations was performed. Subjects were grouped acco...

Background: The incidence and prevalence of overt hypothyroidism have been reported to be 2 to 4/1,000 population/year and 8 to 13/1,000 population, respectively, in foreign countries. As there has been no nationwide survey to obtain data in Korea, the present study investigated the incidence and prevalence of overt hypothyroidism in Korea using claims data provided by the Health Insurance Review and Assessment Service. The proportions of causative diseases for hypothyroidism ...

Background: Selenium is an important trace element for thyroid hormone metabolism and its deficiency can cause hypothyroidism. Serum or plasma selenium concentration has been known as best biomarker which reflects selenium intake and reserve. We preliminarily assessed the serum or urine selenium concentrations in patients with thyroid disease compared to healthy normal population. We also investigated the correlation of serum selenium concentration with urine selenium concentr...

Background: Three deiodinase genes (DIO) play an important role in thyroid hormone metabolism. Among them, type 2 iodothyronine deiodinase (DIO2) converts T4 to T3 in brain and impaired psychological well-being was reported in minor variants of DIO2. However, the prevalence of three DIOs and their relation to neuropsychological status has not been evaluated in Asian hypothyroid subjects.Methods: We prospectively enrolled 196 subjects who were taking levo...

Background: Distant metastasis rarely occurs in differentiated thyroid carcinoma (DTC), but represents most common cause of death in patients with DTC. Lung and bone are the most frequent sites of distant metastases. This study investigated long term outcomes of lung metastasis in DTC patients and its prognostic factors influencing disease progression and cancer specific survival (CSS).Methods: A total of 134 DTC patients presenting with lung metastasis ...

Background: Pregnancy with Cushing syndrome (CS) is rare because infertility is associated with hypogonadotrophic hypogonadism by cortisol and androgens excess. Here we reported the cases of CS that presented signs and symptoms of CS after delivery.Case reports: The first case is a 30-year-old woman who presented 8 months after second baby delivery amenorrhea even though she stopped breastfeeding. For 3 months before her visit, she gained weight and had ...

Objective: Hypoglycemia is a common adverse event and one of the main obstacles to achieving good glycemic control to minimize the risk of diabetic complications in patients with diabetes. Therefore, most physicians try to reduce hypoglycemia events through education about hypoglycaemia, such as diabetes self-management education. In this study, we surveyed the actual insight about hypoglycemia, behavior of diabetic patients to avoid hypoglycemia and the fear of hypoglycemia.<...

The objectives of this study were to investigate intertemporal choice in patients with type 2 Diabetes and whether blood glucose control is related to intertemporal choice. Ninety seven diabetes patients (41 inpatients and 56 outpatients) were recruited. All patients were subjected to the following tests: DM Distress Scale (DDS), Beck Anxiety Inventory (BAI), the Center for Epidemiologic Studies Depression Scale (CES-D) and the Big Five Inventory-K-10 (BFI-K-10). 73 of recruit...

Polycystic ovary syndrome (PCOS) is an endocrinal disorder afflicting women mainly during their childbearing age. The symptoms of PCOS are irregular menstrual cycles, weight gain, subfertility, and infertility. However, since the etiology is as yet unclear, the management and treatment are still not well established. Recently, natural substances have been used for PCOS therapy. Ecklonia cava is a well-known natural substance that attenuates inflammation, allergy and c...

Cuscuta japonica chois (CJC) has been used traditionally to treat sexual disorder and skin problem such as pimples, freckles and melasma in Korea. The present study aimed to investigate the alleviating effect of CJC extract on surgical injury-induced ischemia in the hind-limb of mice. In this study, Female C57BL/6 mice were ovariectomized and excised the vessels of hind-limb after ligated by surgical silk (6-0). The mice were administered with CJC (150 or 450 mg/kg per day) fo...